DeSoto County Mississippi has outdistanced the competition for the past 15 years in new locations and expansions in the Mid South. Southern Business and Development Magazine named us the top small market for new economic development several years ago. Our well diversified industrial base of 185 manufacturers and distributors call Desoto County home thanks in large part to the pro-business attitude and wise infrastructure planning of the local elected officials and aggressive State incentive package. Explore the location advantages by taking a tour of the subcategories listed as you place your cursor over the Economic Development link. Make plans to visit and invest.